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Historically, primary radiation therapy has been used to treat patients with bulky or locally advanced cervical cancer. The approach generally consists of external beam radiation to achieve primary tumor reduction and provide coverage to the parametria and regional nodes at risk, supplemented by brachytherapy to increase radiation dose delivery to the central residual tumor. Earlier attempts to improve outcome results from primary radiation therapy by the addition of agents such as hydroxyurea or hypoxic cell sensitizers met with mixed success. Results from five randomized trials on cervical cancer have established the role of concurrent cisplatinbased chemotherapy and radiation therapy for high-risk or locally advanced disease 29, 3134 ; . The various studies had different eligibility criteria, but in total included a broad spectrum of clinical presentations: 1 ; patients with locally advanced tumors for whom chemoradiation represented primary therapy three studies [31, 32, 34] 2 ; bulky early-stage cancers in which chemoradiation was delivered prior to adjuvant hysterec.

35. DUNITZ, J. D. 1952 The crystal structure of chloramphenicol and bromamphenicol. J. Am. Chem. Soc., 74, 995-999. 36. EHRLICH, J., BARTZ, Q. R., SMITH, R. M., JOSLYN, D. A., AND BURKHOLDER, P. R. 1947 Chloromycetin, a new antibiotic from a soil actinomycete. Science, 106, 417. 37. EPHRUSSI-TAYLOR, H. 1960 On the biological functions of deoxyribonucleic acid. 10th symposium of the Society of General Microbiology. In Microbial genetics, pp. 132-154. Cambridge University Press, London. 38. FASSIN, W., HENGEL, R., AND KLEIN, P. 1955 Bacteriostat and bacteriocide as alternatives of the antibacterial chloramphenicol effect. Z. Hyg. Infektionskrankh., 141, 363-375. 39. FOSTER, J. W. AND PITTILLO, R. F. 1953 Reversal by complex natural materials of growth inhibition caused by antibiotics. J. Bacteriol., 65, 361-367. 40. FOSTER, J. W. AND PITTILLO, R. F. 1953 Metabolite reversal of antibiotic inhibition, especially reversal of Aureomycin inhibition by riboflavin. J. Bacteriol., 66, 478486. 41. FOTER, M. J., PALMER, M., AND MALONEY, T. E. 1953 Antialgal properties of various antibiotics. Antibiotics & Chemotherapy, 3, 505-508. 42. Fox, M. S. AND HOTCHKISS, R. D. 1957 Initiation of bacterial transformation. Nature, 179, 1322-1325. 43. FUSILLO, M. H., METZGER, J. F., AND KUHNS, D. M. 1952 Effect of Chloromyceti and streptomycin on embryonic tissue growth in in vitro tissue culture. Proc. Soc. Exptl. Biol. Med., 79, 376-377. 44. GALE, E. F. AND FOLKES, J. B. 1953 The assimilation of amino-acids by bacteria. 15. Actions of antibiotics on nucleic acid and protein synthesis in Staphylococcus aureus. Biochem. J., 53, 493-498. 45. GALE, E. F. AND PAINE, T. F. 1951 The assimilation of amino-acids by bacteria. 12. The action of inhibitors and antibiotics on the accumulation of free glutamic acid and the formation of combined glutamate in Staphylococcus aureus. Biochem. J., 48, 298-301. 46. GILLIES, N. E. AND ALPER, T. 1959 Reduction in the lethal effects of radiations on Escherichia coli by treatment with chloramphenicol. Nature, 183, 237-238. 47. GLASS, E. A. AND NOVICK, A. 1959 Induc and chloramphenicol.
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3506 Comment: A commenter asked how beneficiaries will know that OVHA might pay or subsidize a higher premium, and suggested that beneficiaries be notified. During the legislative session, the discussion with OVHA explained that this was a secondary implementation possibility. Therefore, the language uses the word "may." This possibility will be analyzed during the first several months of MMA implementation and, if appropriate, a procedure drafted for later operational implementation. This procedure may need review and approval by the Centers for Medicare and Medicaid Services CMS ; and therefore was not implemented prior to 1, for instance, elase chloromycetin. 39. Scott DA: Vaccines against Campylobacter jejuni. J Infect Dis 1997; 176 Suppl 2 ; : S183 8. 40. Lee LH, Burg E, Baqar S, et al: Evaluation of a truncated recombinant flagellin subunit vaccine against Campylobacter jejuni. Infect Immunol 1999; 67: 5799 Baqar S, Bourgeois AL, Schultheiss PJ, et al: Safety and immunogenicity of a prototype oral whole-cell killed Campylobacter vaccine administered with a mucosal adjuvant in non-human primates. Vaccine 1995; 13: 22 Hoge CW, Gambel JM, Srijan A, Pitarangsi C, Echeverria P: Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years. Clin Infect Dis 1998; 26: 3415. Kuschner RA, Trofa AF, Thomas RJ, et al: Use of azithromycin for the treatment of Campylobacter enteritis in travelers to Thailand, an area where ciprofloxacin resistance is prevalent. Clin Infect Dis 1995; 21: 536 Bayne-Jones S: The Evolution of Preventive Medicine in the United States Army, 16071939, pp 123 46. Washington, DC, Office of the Surgeon General, Department of the Army, 1968. 45. Siler JF, Lambie JS: Typhoid and the paratyphoid fevers. In: The Medical Department of the United States Army in the World War, Vol IX, pp 15 60. Edited by Lynch C, Weed FW, McAfee L. Washington, DC, Office of the Surgeon General, Department of the Army, 1928. 46. Woodward TE, Smadel JE, Ley HL, Green R, Mankikan DS: Preliminary report on beneficial effect of chlroomycetin in treatment of typhoid fever. Ann Intern Med 1948; 29: 131 Hoffman SL, Punjabi NH, Kumala S, et al: Reduction of mortality in chloramphenicol-treated severe typhoid fever by high-dose dexamethasone. N Engl J Med 1984; 310: 82 Tribble D, Girgis N, Habib N, Butler T: Efficacy of azithromycin for typhoid fever. Clin Infect Dis 1995; 21: 1045 Frenck RW, Nakhla I, Sultan Y, et al: Azithromycin versus ceftriaxone for the treatment of uncomplicated typhoid fever in children. Clin Infect Dis 2000; 31: 1134 Girgis NI, Butler T, Frenck RW, et al: Azithromycin versus ciprofloxacin for treatment of uncomplicated typhoid fever in a randomized trial in Egypt that included patients with multidrug resistance. Antimicrob Agents Chemother 1999; 43: 1441 Wallace MR, Yousif AA, Mahroos GA, et al: Ciprofloxacin versus ceftriaxone in the treatment of multiresistant typhoid fever. Eur J Clin Microbiol Infect Dis 1993; 12: 90710. Gaines S, Landy M, Edsall G, Mandel AD, Trapani RJ, Benenson AS: Studies on infection and immunity in experimental typhoid fever. III. Effect of prophylactic immunization. J Exp Med 1961; 114: 327 Wahdan MH, Serie C, Germanier R, et al: A controlled field trial of liver oral typhoid vaccine Ty21a. Bull World Health Organ 1980; 58: 469 Kean BH: The diarrhea of travelers to Mexico: summary of five-year study. Ann Intern Med 1963; 59: 60514. Hyams KC, Bourgeois AL, Merrell BR, et al: Diarrheal disease during Operation Desert Shield. N Engl J Med 1991; 325: 1423 Hoge CW, Gambel JM, Srijan A, Pitarangsi C, Echeverria P: Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years. Clin Infect Dis 1998; 26: 3415. Taylor DN, Echeverria P: Etiology and epidemiology of travelers' diarrhea in Asia. Rev Infect Dis 1986; 8 Suppl 2 ; : S136 41. 58. Bayne-Jones S: The Evolution of Preventive Medicine in the United States Army, 16071939, pp 5759. Washington, DC, Office of the Surgeon General, Department of the Army, 1968. 59. Hume EE: Victories of Army Medicine: Scientific Accomplishments of the Medical Department of the United States Army. Philadelphia, PA, J.P. Lippincott, 1943. 60. Darnall CR: The purification of water by anhydrous chlorine. J Public Health Assoc 1911; 1: 78397. Lyster WJ: Sterilization of drinking water by calcium hypochlorite in the field. Milit Surg 1915; 36: 222 Wood MJ, Hornick RB: Commission on enteric infections. In: The Armed Forces Epidemiological Board: Histories of the Commissions, pp 385 436. Edited by Woodward TE. Washington, DC, Borden Institute, Office of the Surgeon General, Department of the Army, 1994. 63. DuPont HL, Formal SB, Hornick RB, et al: Pathogenesis of Escherichia coli diarrhea. N Engl J Med 1971; 285: 19. Wolf MK, Taylor DN, Boedeker EC, et al: Characterization of enterotoxigenic Escherichia coli isolated from U.S. troops deployed to the Middle East. J Clin Microbiol 1993; 31: 851 Wolf MK: Occurrence, distribution, and associations of O and H serogroups and chloramphenicol.
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Please post this 2003 holiday schedule in your laboratory. If you have any questions about staffing at the N.C. State Laboratory of Public Health or specimen submissions during the holidays, please contact the following sections prior to submitting specimens. Cancer Cytology Environmental Sciences Microbiology Newborn Screening Clinical Chemistry Virology Serology 919-733-7146 919-733-7308 919-733-7367.

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