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The MICs for the 37 EMB-resistant isolates were correlated with the mutations. Of the nine isolates with mutation at codon 306, six had MIC 10 g ml, one had 8 g ml and two were inhibited at 6 g EMB concentration Table 2 ; . However, isolates with mutation other than Met306 had an MIC 10 g ml, except three isolates Table 2 ; . No correlation could be observed between MICs for strains with single or multiple mutations. Mutation associated EMB resistance was found to be present mostly with multidrug resistance, i.e. along with resistance to INH and RIF. The resistance profile of isolates with nucleotide polymorphism, either at ERDR or other loci, is given in Table 1. The present study provides additional molecular evidence on EMB-resistant clinical isolates from the Indian subcontinent. The target for EMB is the EmbB protein encoded by the embB gene of operon embCAB in M. tuberculosis5, 10 . Mutations in the operon embCAB of M. tuberculosis and M. smegmatis have been shown to be associated with EMB resistance10 . Certain mutations, particularly at the amino acid position 306 of embB were found to be associated exclusively with EMB-resistant M. tuberculosis9, 10, 17, 18 . Thus, embB is regarded as ERDR. Worldwide studies10, 19 report that percentage of EMBresistant strains with mutation in embB gene varies from 50 to 60%; no such report has been documented from the Indian subcontinent, which contributes one-third of global TB. Besides the documented mutation at amino acid position 306 of the embB gene, we observed few novel mutations in our study not reported so far. The most frequent mutation observed was at ERDR, i.e. codon Met306 being replaced by Leu, Ile or Val. The other most frequent mutation encountered was Asp299Glu 6 22 ; followed by Asn296Lys 2 22 ; . Mutation at codon Leu304Trp and Val282Gly was present in a single isolate each. However, we did not find any isolate with mutation at amino acid Trp as observed by Lee et al.19 in EMB-resistant M. tuberculosis isolates from Korea. A wide range of mutations other than Met306 have been reported, previously by Sreevatsan et al. 9 and later by Ramaswamy et al. 11 . These strains included either of the three gr I katG463 CTG plus gyrA95 ACC; gr II katG463 CGG plus gyrA95 ACC; gr III katG463 CGG plus gyrA95 AGC ; principle genetic, because norsette tablets.
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